In Vivo Seeding and Cross-Seeding of Localized Amyloidosis
نویسندگان
چکیده
منابع مشابه
Proteopathic tau seeding predicts tauopathy in vivo.
Transcellular propagation of protein aggregates, or proteopathic seeds, may drive the progression of neurodegenerative diseases in a prion-like manner. In tauopathies such as Alzheimer's disease, this model predicts that tau seeds propagate pathology through the brain via cell-cell transfer in neural networks. The critical role of tau seeding activity is untested, however. It is unknown whether...
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The epidemics of bovine spongiform encephalopathy (BSE) several decades ago and present epidemics of chronic wasting disease (CWD) among cervids posed a threat of cross-species infections to humans or other animals. Therefore, the question as to the molecular nature of the species barriers to transmissibility of prion diseases is very important. We approached this problem theoretically, first d...
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This research studies the optimal seeding of a network of consumers who are potential adopters of a technology. This problem has a wide range of applications which include launching a network good, inducing network-based marketing, igniting collaboration in organizations, and stimulating R&D with local spillovers. I have two main results so far. The first result shows that when a firm is unawar...
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With the climbing costs of cotton production, producers must ensure optimal returns on their cotton crops in order to make a profit. The groundwork for a high yielding crop has to start with an accurate and efficient planting system to ensure an optimal stand. However, there are a variety of new systems and techniques to incorporate compared to the conventional system that has been used for so ...
متن کاملCross-seeding effects of amyloid β-protein and α-synuclein.
Amyloid β-protein (Aβ) and α-synuclein (αS) are the primary components of amyloid plaques and Lewy bodies (LBs), respectively. Previous in vitro and in vivo studies have suggested that interactions between Aβ and αS are involved in the pathogenesis of Alzheimer's disease and LB diseases. However, the seeding effects of their aggregates on their aggregation pathways are not completely clear. To ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2015
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2014.11.016